RESUMO
OBJECTIVE: Assessment of neurobehavior and visual function of newborns with congenital heart disease during the post-operative period to identify infants at risk of neurodevelopmental and visual impairment. STUDY DESIGN: Prospective study that included 45 newborns who underwent cardiac surgery. Newborn Behavioral Observations test (NBO) and "ML Battery of Optotypes" were used for assessment. RESULTS: The median NBO global score was 2.4 [2.1-2.6]. Total days of oral morphine [p = 0.005] and total days of sedation [p = 0.009] were strongly related to abnormal evaluations. Time of cerebral regional oxygen saturation (CrSO2) under 40% during surgery and increased lactate were related to abnormal motor evaluation. Only 14.5% of patients presented pathological results in visual evaluation. CONCLUSIONS: We have demonstrated alterations in attention, autonomic, motor, and oral motor function. Duration of sedative medication, time of CrSO2 under 40% during surgery, and increased lactate are the most important risk factors. No significant visual impairment was detected.
Assuntos
Procedimentos Cirúrgicos Cardíacos , Cardiopatias Congênitas , Lactente , Humanos , Recém-Nascido , Estudos Prospectivos , Cardiopatias Congênitas/etiologia , Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Transtornos da Visão/diagnóstico , Transtornos da Visão/etiologia , Lactatos , OxigênioRESUMO
Subcutaneous fat necrosis (SCFN) is a rare entity that occurs generally in term or post-term newborns exposed to perinatal stressing factors. These cutaneous lesions appear during the first weeks of life and their potential complications, such as hypercalcemia, determine the prognosis. We present a full-term newborn with SCFN lesions that appeared at the age of 12 days and who, 1 week later, developed moderate hypercalcemia. In our patient, the standard treatment was not enough to normalize calcemia and, in order to prevent secondary effects, etidronate therapy was initiated and it successfully normalized calcium levels. When SCFN is diagnosed, it is important to detect early hypercalcemia and treat it aggressively. This case provides further evidence of etidronate as an alternative and effective treatment for moderate-severe hypercalcemia.
Assuntos
Conservadores da Densidade Óssea/uso terapêutico , Ácido Etidrônico/uso terapêutico , Necrose Gordurosa/complicações , Hipercalcemia/tratamento farmacológico , Hipóxia-Isquemia Encefálica/complicações , Gordura Subcutânea/patologia , Humanos , Hipercalcemia/etiologia , Lactente , Masculino , Resultado do TratamentoRESUMO
No disponible
